Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by in Vitro Autoradiography : Changes in Dopamine D_1 and Serotonin 5-HT_ Receptor Binding

概要

Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on specific [^3H] SCH23390 binding to dopamine D_1 receptors and [^3H] ketanserine binding to serotonin 5-HT_<2A> receptors in the rat brain. Specific binding of both compounds was affected by aging. Long-term administration of KKT resulted in decreases in [^3H] SCH23390 binding to the cortex and hippocampus in aged rats, and in decreases in [^3H] ketanserine binding to the caudate/putamen in young rats. These results suggest that the changes in dopamine D_1 and serotonin 5-HT_<2A> receptor binding may be involved in the central effects of KKT.

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